Remission of Acquired Factor-VIII-Inhibitor-Induced Bleeding
نویسندگان
چکیده
منابع مشابه
Acquired factor VIII inhibitor.
PERSISTENT or uncontrolled bleeding is one of the most feared consequences of any surgical procedure. Numerous factors can contribute to its etiology. Among these, both inherited and acquired disorders of coagulation and/or thrombocyte function need to be taken into account. Acquired hemophilia can be caused by antibodies to coagulation factors. Antibodies can arise in hemophilic or nonhemophil...
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Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
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Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient's plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modi...
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Bleeding caused by the acquired production of inhibitors to factor VIII is a rare medical emergency that may arise spontaneously in post-partum women, and in patients with cancer or autoimmune disorders. It can also occur as a result of drug reactions or even in previously healthy patients. The immediate initiation of therapy with high-dose factor VIII concentrates may be life-saving. The mecha...
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The present study reports on the treatment of bleeding episodes and the natural history of factor VIII inhibitors in 4 patients with acquired haemophilia A postpartum. Low titre type II factor VIII inhibitors in 3 patients and high titre type I inhibitor in 1 patient became apparent immediately to 7 months after delivery. High dose human factor VIII concentrate substitution was effective in con...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 1980
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000207240